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ARTICLES
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5289-5310
| Synthesis and Structure-Activity Relationships of New 1,3-Disubstituted Cyclohexanes as Structurally Rigid Leukotriene B4 Receptor Antagonists
Jean-Marc Poudrel,
Pierre Hullot,
Jean-Pierre Vidal,
Jean-Pierre Girard,
Jean-Claude Rossi,
Agnès Muller,
Claude Bonne,
Vladimir Bezuglov,
Igor Serkov,
Pierre Renard, and
Bruno Pfeiffer
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5311-5324
| Na+-Glucose Cotransporter (SGLT) Inhibitors as Antidiabetic Agents. 4. Synthesis and Pharmacological Properties of 4'-Dehydroxyphlorizin Derivatives Substituted on the B Ring
Kenji Tsujihara,
Mitsuya Hongu,
Kunio Saito,
Hiroyuki Kawanishi,
Kayoko Kuriyama,
Mamoru Matsumoto,
Akira Oku,
Kiichiro Ueta,
Minoru Tsuda, and
Akira Saito
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5325-5337
| Molecular Recognition of Modified Adenine Nucleotides by the P2Y1-Receptor. 1. A Synthetic, Biochemical, and NMR Approach
Efrat Halbfinger,
Dan T. Major,
Marco Ritzmann,
Joachim Ubl,
Georg Reiser,
Jose L. Boyer,
Kendall T. Harden, and
Bilha Fischer
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5338-5347
| Molecular Recognition of Modified Adenine Nucleotides by the P2Y1-Receptor. 2. A Computational Approach
Dan T. Major,
Efrat Halbfinger, and
Bilha Fischer
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5348-5358
| Comparative Molecular Field Analysis of Fungal Squalene Epoxidase Inhibitors
Vijay M. Gokhale and
Vithal M. Kulkarni
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5359-5368
Exploring the Structure-Activity Relationships of [1-(4-tert-Butyl-3'-hydroxy)benzhydryl-4-benzylpiperazine] (SL-3111), A High-Affinity and Selective  -Opioid Receptor Nonpeptide Agonist Ligand
Josue Alfaro-Lopez,
Toru Okayama,
Keiko Hosohata,
Peg Davis,
Frank Porreca,
Henry I. Yamamura, and
Victor J. Hruby
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5369-5389
| Design and Structure-Activity Relationship of a New Class of Potent VEGF Receptor Tyrosine Kinase Inhibitors
Laurent F. Hennequin,
Andrew P. Thomas,
Craig Johnstone,
Elaine S. E. Stokes,
Patrick A. Plé,
Jean-Jacques M. Lohmann,
Donald J. Ogilvie,
Mike Dukes,
Steve R. Wedge,
Jon O. Curwen,
Jane Kendrew, and
Christine Lambert-van der Brempt
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5390-5401
| Modeling of Amino-Terminal Domains of Group I Metabotropic Glutamate Receptors: Structural Motifs Affecting Ligand Selectivity
Gabriele Costantino,
Antonio Macchiarulo, and
Roberto Pellicciari
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5402-5414
Selective Inhibitors of Glial GABA Uptake: Synthesis, Absolute Stereochemistry, and Pharmacology of the Enantiomers of 3-Hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole (exo-THPO) and Analogues
Erik Falch,
Jens Perregaard,
Bente Fr lund,
Birgitte Skilde,
Anders Buur,
Lene M. Hansen,
Karla Frydenvang,
Lotte Brehm,
Tina Bolvig,
Orla M. Larsson,
Connie Sanchez,
Harold S. White,
Arne Schousboe, and
Povl Krogsgaard-Larsen
[Full Article -
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5415-5425
| Synthesis, Characterization, and Structure-Activity Relationships of Amidine-Substituted (Bis)benzylidene-Cycloketone Olefin Isomers as Potent and Selective Factor Xa Inhibitors
William J. Guilford,
Kenneth J. Shaw,
Jerry L. Dallas,
Sunil Koovakkat,
Wheeseong Lee,
Amy Liang,
David R. Light,
Margaret A. McCarrick,
Marc Whitlow,
Bin Ye, and
Michael M. Morrissey
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5426-5436
| Design, Synthesis, and Biological Evaluation of Matrix Metalloproteinase Inhibitors Derived from a Modified Proline Scaffold
Menyan Cheng,
Biswanath De,
Neil G. Almstead,
Stanislaw Pikul,
Martin E. Dowty,
Charles R. Dietsch,
C. Michelle Dunaway,
Fei Gu,
Lily C. Hsieh,
Michael J. Janusz,
Yetunde O. Taiwo, and
Michael G. Natchus
, Tomas Hudlicky and
Martin Mandel
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5437-5447
| 2-(Diethylamino)thieno[1,3]oxazin-4-ones as Stable Inhibitors of Human Leukocyte Elastase
Michael Gütschow,
Lars Kuerschner,
Ulf Neumann,
Markus Pietsch,
Reik Löser,
Norman Koglin, and
Kurt Eger
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5448-5454
| Inhibition of Trypanosoma cruzi Trypanothione Reductase by Acridines: Kinetic Studies and Structure-Activity Relationships
Susanne Bonse,
Christiane Santelli-Rouvier,
Jacques Barbe, and
R. Luise Krauth-Siegel
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5455-5463
| Probes for Narcotic Receptor Mediated Phenomena. 26. Synthesis and Biological Evaluation of Diarylmethylpiperazines and Diarylmethylpiperidines as Novel, Nonpeptidic Opioid Receptor Ligands
Xiaoyan Zhang,
Kenner C. Rice,
Silvia N. Calderon,
Hiroshi Kayakiri,
Larren Smith,
Andrew Coop,
Arthur E. Jacobson,
Richard B. Rothman,
Peg Davis,
Christina M. Dersch, and
Frank Porreca
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5464-5474
| Tyrosine Kinase Inhibitors. 16. 6,5,6-Tricyclic Benzothieno[3,2-d]pyrimidines and Pyrimido[5,4-b]- and -[4,5-b]indoles as Potent Inhibitors of the Epidermal Growth Factor Receptor Tyrosine Kinase
H. D. Hollis Showalter,
Alexander J. Bridges,
Hairong Zhou,
Anthony D. Sercel,
Amy McMichael, and
David W. Fry
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BRIEF ARTICLES
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5475-5481
| Synthesis and Biological Evaluation of Dihydrobenzofuran Lignans and Related Compounds as Potential Antitumor Agents that Inhibit Tubulin Polymerization
Luc Pieters,
Stefaan Van Dyck,
Mei Gao,
Ruoli Bai,
Ernest Hamel,
Arnold Vlietinck, and
Guy Lemière
[Full Article -
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5482-5486
| Combined Effect of Platination and Intercalation upon DNA Binding of Novel Cytotoxic Pt-Bis(naphthalimide) Complexes
José M. Pérez,
Isabel López-Solera,
Eva I. Montero,
Miguel F. Braña,
Carlos Alonso,
Simon P. Robinson, and
Carmen Navarro-Ranninger
[Full Article -
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5487-5493
| Novel, Potent, Semisynthetic Antimalarial Carba Analogues of the First-Generation 1,2,4-Trioxane Artemether
Paul M. O'Neill,
Natalie L. Searle,
Ka-Wing Kan,
Richard C. Storr,
James L. Maggs,
Stephen A. Ward,
Kaylene Raynes, and
B. Kevin Park
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